Antidepressant medication can be a bit tricky sometimes, too. If one isn't working, then maybe you need to be tapered off, and tapered on to a new one. There's a good chance that your IC may not know all of the nuances with AD medication. Perhaps they can recommend a good psychiatrist to help you in that regard, though.
I believe therapy in one form or another is important to treating depression. One book that my therapist recommended to me which was helpful was "Feeling Good: The New Mood Therapy" by David Burns. Burns takes more of a holistic and non-medicinal approach to treating depression. He really has some good methods in there.
One thing I would suggest is to get out and make the most of each day. Even if you wake up not feeling like doing anything, "prime the pump", so to speak, by doing something, and the day's physical and social activities will fall into place easier.
Best of luck to you. Hope your upcoming IC appointment is helpful to you!