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I've recently added a fourth med to my regimen, Wellbutrin. I've been on it a week now and I feel a tiny bit better, I can't decide if it's actually working or just the placebo effect. How long did it take you to start feeling better?

I've been on Wellbutrin since around late April/early May 2014. My doctor started me on a low dose, but it was several months before I began to notice positive changes because a) I had been diagnosed with major depression, and b) the dose was too low (150 mg instead of 300 mg).

It was a very gradual change for me, so others began to notice before I did. Weird, right?

I do know that Wellbutrin isn't like SSRI ADs, but I don't think that means it's not possible for you to be experiencing some positive effects already.

I was on it for about 18 months. It took 2 or 3 weeks to kick in.

I always refer to my depression as walking through a downpour. Wellbutrin didn't make the rain go away. It gave me an umbrella.

I've been on it since 2014. Thank god bc I can't imagine surviving dday this past February if I wasn't on it!!!

I've been on Wellbutrin for about two years. I have found that it deals with most of my depression without dampening my emotions completely. I am ASD so I am not sure my responses are the norm, but it has worked well for me.

I take 150 mg in the morning and another in the afternoon.

For me, I could tell within a couple of weeks it was making me much worse. It's probably different for everyone, but at least a month to six weeks seems to be the standard trial period to see if it's working or not.

I take 300 mg Wellbutrin. I feel like it dries up the tears, but I'm still sad. I'm too scared to get off of it. I've been taking it for about 2 years.

I've been on it about 2 years now and really not sure if I need it anymore. I'm afraid to come off though.

(((Freetogoknow)))

I hope this change in. Medication is a success for you. I have a lot of hope and trust in your treatment so far. It seems to be going in a positive and thoughough course. Your ic sounds amazing and supportive of your wellbeing.

I say give it some time. Even the placebo effect on your mental health is needed if nothing else.

I'm so glad you are feeling better.

😙❤

I have been on Welbutrin on and off since 1994 or so. I was originally diagnosed with seasonal affective disorder, which diagnosis has since been changed to major depressive disorder.

Welbutrin has been a life-changer for me. When I stupidly go off it, I notice the difference right away. When I am not medicated, I am completely unable to deal with setbacks in life. I get suicidal and feel like problems in life are insurmountable. When I am properly medicated I can tackle problems as I imagine every normal person would.

I have been on Welbutrin on and off since 1994 or so. I was originally diagnosed with seasonal affective disorder, which diagnosis has since been changed to major depressive disorder.

Welbutrin has been a life-changer for me. When I stupidly go off it, I notice the difference right away. When I am not medicated, I am completely unable to deal with setbacks in life. I get suicidal and feel like problems in life are insurmountable. When I am properly medicated I can tackle problems as I imagine every normal person would.

I took Wellbutrin a few years ago when I was struggling with depression (situational). I remember I felt tired the first few days I took it, but maybe that was just the depression. I was seeing a counselor every other week, and while I can't remember exactly when I felt better, it was definitely within a month or two. I ended up taking if for 18 months and then weaned off of it. I hope it helps you!

I've been on and off Wellbutrin for quite a few years. I've tried several other antidepressants that did nothing except cause "sexual side effects" or weight gain. Wellbutrin had the opposite effect in both of those areas.

It did take some getting used to at first. I felt kind of jittery and had mouth dryness but that went away after a few weeks. I think within 2 weeks of starting it I was feeling pretty good.

I've been on 300mg for about 1.5 years now. It is hard to say how long it takes because there is no "a switch just flipped" kind of feeling, but I think I started to feel it about 2 weeks in and felt much better at 2 months. I still take it and have no plans to stop. I do not take any other meds for depression.

I was diagnosed with Major depressive disorder, DDNOS and complex PTSD. Wellbutrin was my first line of defense and then therapy.

Wellbutrin is very mild, and different from SSRI's. This is from Medicinenet:

Wellbutrin works by inhibiting the reuptake of dopamine, serotonin, and norepinephrine; an action that results in more dopamine, serotonin, and norepinephrine to transmit messages to other nerves.

In other words, it helps increase the chemicals in our brains that make us happy, to help counter-act the depression. Since these are our brains own, normal chemicals, the result "feels" natural.

As WarriorPrincess said, it helps me feel "normal" in dealing with stress. I would not hesitate to recommend it to others.

[This message edited by DaddyDom at 4:40 PM, September 11th (Monday)]

Did the Wellbutrin cause any weight loss for anybody? I've considered asking doctor to try this medication over ssri.

I would swear I'm feeling the effects of it. I might actually start getting stuff done around here.

Im not sure about weight loss specifically but it does help me avoid emotional eating. I have a lot of weight issues anyway so its hard to tell.

I also noticed that I smoked less when I was on it. Buproprion (the generic name for Welbutrin) is or was also marketed as a way to help people quit smoking.

"Im not sure about weight loss specifically but it does help me avoid emotional eating. I have a lot of weight issues anyway so its hard to tell.

I also noticed that I smoked less when I was on it. Buproprion (the generic name for Welbutrin) is or was also marketed as a way to help people quit smoking."

I believe it works largely on the dopamine re uptake system, thus making sure enough of the motivation/reward neurochemical is circulating, so it makes sense it would improve mood and curb cravings. I also find it helps food cravings and I feel quite lively on it.

I hope you continue to have good results with Wellbutrin. I tried it once several years ago but it didn't work out for me. I'm sensitive to AD's and easily pushed over the edge, especially if I have caffeine. I ended up with severe panic attacks. Good times.

I can't speak to the weight loss part, but I've been taking Cymbalta for about 5 years and it's been great! It is often used for people with chronic pain and has the benefit of some weight loss for a lot of people. It's an SNRI rather than an SSRI, which has made all the difference for me.

A fun fact that my NP told me years ago is that nicotine is somewhat of an antidepressant, which is part of the reason Wellbutrin works so well to help people quit smoking. It's how many providers got around insurance companies. If it was prescribed for smoking cessation, they wouldn't cover it. But if you got a depression diagnosis and it was prescribed for that they would cover it.